I am on Crystal Reports 2008 SP6 and am experiencing the same...
I've checked the registry entries under HKCR\CrystalReports\shell\Open\ except I have another entry for command: 8GO+%q=bMAJ0e_p{6iZScrw>IWZ^CAp&e@DM$D`aZ`y3 /dde
I can't seem to find the key mentioned by Ludek in HKLM\Software\Classes\CrystalReportsLauncher...I don't even have a key close to that.
Anything else I can check or try?